Endocrine Abstracts

There is a paucity of information regarding the genetic and somatic mutation events that lead to the production of pathogenic thyroid stimulating antibodies (TSAbs) in Graves’ disease. We have previously isolated two murine monoclonal antibodies (KSAb1 and KSAb2) with potent TSAb activity that demonstrate subtle differences in their interaction with the thyrotropin receptor (TSHR). Analyses of the variable region genes of the heavy and light chains of these TSAbs were per...